ASK1           Alternative name(s) : Mitogen activated kinase kinase kinase 5 ;  MAP/ERK kinase kinase 5 ;  MEKK5 ;  MAPKKK5 ;  Apoptosis signal regulating kinase 1 ;  MAP3K5 ;    Molecular Class : Serine/threonine kinase       Biological Process : Cell communication and signal transduction  Gene symbol :   MAP3K5   PPD ID :   HPRD_03904  Gene map locus : 6q22.33 Peptide Data MRM Exosome Data Proteinpedia Data is not present Expression Architecture Cellular Component Links OMIM 602448 Entrez Gene   4217 HGNC HGNC:6857 UniProt Q99683 HPRD 03904  NetPath NetPath_M4217 PTM SNP Disease   Data is not present     Protein Sequence : NP_005914.1    MSTEADEGIT FSVPPFAPSG FCTIPEGGIC RRGGAAAVGE GEEHQLPPPP PGSFWNVESA AAPGIGCPAA TSSSSATRGR GSSVGGGSRR TTVAYVINEA SQGQLVVAES EALQSLREAC ETVGATLETL HFGKLDFGET TVLDRFYNAD IAVVEMSDAF RQPSLFYHLG VRESFSMANN IILYCDTNSD SLQSLKEIIC QKNTMCTGNY TFVPYMITPH NKVYCCDSSF MKGLTELMQP NFELLLGPIC LPLVDRFIQL LKVAQASSSQ YFRESILNDI RKARNLYTGK ELAAELARIR QRVDNIEVLT ADIVINLLLS YRDIQDYDSI VKLVETLEKL PTFDLASHHH VKFHYAFALN RRNLPGDRAK ALDIMIPMVQ SEGQVASDMY CLVGRIYKDM FLDSNFTDTE SRDHGASWFK KAFESEPTLQ SGINYAVLLL AAGHQFESSF ELRKVGVKLS SLLGKKGNLE KLQSYWEVGF FLGASVLAND HMRVIQASEK LFKLKTPAWY LKSIVETILI YKHFVKLTTE QPVAKQELVD FWMDFLVEAT KTDVTVVRFP VLILEPTKIY QPSYLSINNE VEEKTISIWH VLPDDKKGIH EWNFSASSVR GVSISKFEER CCFLYVLHNS DDFQIYFCTE LHCKKFFEMV NTITEEKGRS TEEGDCESDL LEYDYEYDEN GDRVVLGKGT YGIVYAGRDL SNQVRIAIKE IPERDSRYSQ PLHEEIALHK HLKHKNIVQY LGSFSENGFI KIFMEQVPGG SLSALLRSKW GPLKDNEQTI GFYTKQILEG LKYLHDNQIV HRDIKGDNVL INTYSGVLKI SDFGTSKRLA GINPCTETFT GTLQYMAPEI IDKGPRGYGK AADIWSLGCT IIEMATGKPP FYELGEPQAA MFKVGMFKVH PEIPESMSAE AKAFILKCFE PDPDKRACAN DLLVDEFLKV SSKKKKTQPK LSALSAGSNE YLRSISLPVP VLVEDTSSSS EYGSVSPDTE LKVDPFSFKT RAKSCGERDV KGIRTLFLGI PDENFEDHSA PPSPEEKDSG FFMLRKDSER RATLHRILTE DQDKIVRNLM ESLAQGAEEP KLKWEHITTL IASLREFVRS TDRKIIATTL SKLKLELDFD SHGISQVQVV LFGFQDAVNK VLRNHNIKPH WMFALDSIIR KAVQTAITIL VPELRPHFSL ASESDTADQE DLDVEDDHEE QPSNQTVRRP QAVIEDAVAT SGVSTLSSTV SHDSQSAHRS LNVQLGRMKI ETNRLLEELV RKEKELQALL HRAIEEKDQE IKHLKLKSQP IEIPELPVFH LNSSGTNTED SELTDWLRVN GADEDTISRF LAEDYTLLDV LYYVTRDDLK CLRLRGGMLC TLWKAIIDFR NKQT Molecular weight (Da): 154536  Protein Length : 1374     Nucleotide Sequence : NM_005923.3  Open reading frame: 362 to 4486  CGAGCGCGGC GCCCTTGAGC TGCACCGCGG CGCAGGTTTG CGAGCCGACT TGTCAGCCGG CCAAGAAAAG GAAGCTCCGT CCCTTCCCGC TCACCCGGCT TCCCCACCCC TTGTACTCTA AACTCTGCAG AGGGCGAGCG GCGCGGCCAC GGAGGCGCCG AGGAGGAGCG AGCCGCCGCC GGGCAGCGGC GTGCCCTCGG GGGAGAGGGC GCCGGAGAGG AGGCGGCGGC GCGGCGGCGA GGGCGCGGCG CGCGATGGCA GCTGCTTAGC CCGGCGGGCG CGGAGCAGCC CCGAGCTGTG GCTGGCCAGG CGGTGCGGCT GGGCGGGGGA CGCCGCCGCC GTTGCTGCCC GGCCCGGAGA GATGAGCACG GAGGCGGACG AGGGCATCAC TTTCTCTGTG CCACCCTTCG CCCCCTCGGG CTTCTGCACC ATCCCCGAGG GCGGCATCTG CAGGAGGGGA GGAGCGGCGG CGGTGGGCGA GGGCGAGGAG CACCAGCTGC CACCGCCGCC GCCGGGCAGC TTCTGGAACG TGGAGAGCGC CGCTGCCCCT GGCATCGGTT GTCCGGCGGC CACCTCCTCG AGCAGTGCCA CCCGAGGCCG GGGCAGCTCT GTTGGCGGGG GCAGCCGACG GACCACGGTG GCATATGTGA TCAACGAAGC GAGCCAAGGG CAACTGGTGG TGGCCGAGAG CGAGGCCCTG CAGAGCTTGC GGGAGGCGTG CGAGACAGTG GGCGCCACCC TGGAAACCCT GCATTTTGGG AAACTCGACT TTGGAGAAAC CACCGTGCTG GACCGCTTTT ACAATGCAGA TATTGCGGTG GTGGAGATGA GCGATGCCTT CCGGCAGCCG TCCTTGTTTT ACCACCTTGG GGTGAGAGAA AGTTTCAGCA TGGCCAACAA CATCATCCTC TACTGTGATA CTAACTCGGA CTCTCTGCAG TCACTGAAGG AAATAATTTG CCAGAAGAAT ACTATGTGCA CTGGGAACTA CACCTTTGTT CCTTACATGA TAACTCCACA TAACAAAGTC TACTGCTGTG ACAGCAGCTT CATGAAGGGG TTGACAGAGC TCATGCAACC GAACTTCGAG CTGCTTCTTG GACCCATCTG CTTACCTCTT GTGGATCGTT TTATTCAACT TTTGAAGGTG GCACAAGCAA GTTCTAGCCA GTACTTCCGG GAATCTATAC TCAATGACAT CAGGAAAGCT CGTAATTTAT ACACTGGTAA AGAATTGGCA GCTGAGTTGG CAAGAATTCG GCAGCGAGTA GATAATATCG AAGTCTTGAC AGCAGATATT GTCATAAATC TGTTACTTTC CTACAGAGAT ATCCAGGACT ATGATTCTAT TGTGAAGCTG GTAGAGACTT TAGAAAAACT GCCAACCTTT GATTTGGCCT CCCATCACCA TGTGAAGTTT CATTATGCAT TTGCACTGAA TAGGAGAAAT CTCCCTGGTG ACAGAGCAAA AGCTCTTGAT ATTATGATTC CCATGGTGCA AAGCGAAGGA CAAGTTGCTT CAGATATGTA TTGCCTAGTT GGTCGAATCT ACAAAGATAT GTTTTTGGAC TCTAATTTCA CGGACACTGA AAGCAGAGAC CATGGAGCTT CTTGGTTCAA AAAGGCATTT GAATCTGAGC CAACACTACA GTCAGGAATT AATTATGCGG TCCTCCTCCT GGCAGCTGGA CACCAGTTTG AATCTTCCTT TGAGCTCCGG AAAGTTGGGG TGAAGCTAAG TAGTCTTCTT GGTAAAAAGG GAAACTTGGA AAAACTCCAG AGCTACTGGG AAGTTGGATT TTTTCTGGGG GCCAGCGTCC TAGCCAATGA CCACATGAGA GTCATTCAAG CATCTGAAAA GCTTTTTAAA CTGAAGACAC CAGCATGGTA CCTCAAGTCT ATTGTAGAGA CAATTTTAAT ATATAAGCAT TTTGTGAAAC TGACCACAGA ACAGCCTGTG GCCAAGCAAG AACTTGTGGA CTTTTGGATG GATTTCCTGG TCGAGGCCAC AAAGACAGAT GTTACTGTGG TTAGGTTTCC AGTATTAATA TTAGAACCAA CCAAAATCTA TCAACCTTCT TATTTGTCTA TCAACAATGA AGTTGAGGAA AAGACAATCT CTATTTGGCA CGTGCTTCCT GATGACAAGA AAGGTATACA TGAGTGGAAT TTTAGTGCCT CTTCTGTCAG GGGAGTGAGT ATTTCTAAAT TTGAAGAAAG ATGCTGCTTT CTTTATGTGC TTCACAATTC TGATGATTTC CAAATCTATT TCTGTACAGA ACTTCATTGT AAAAAGTTTT TTGAGATGGT GAACACCATT ACCGAAGAGA AGGGGAGAAG CACAGAGGAA GGAGACTGTG AAAGTGACTT GCTGGAGTAT GACTATGAAT ATGATGAAAA TGGTGACAGA GTCGTTTTAG GAAAAGGCAC TTATGGGATA GTCTACGCAG GTCGGGACTT GAGCAACCAA GTCAGAATTG CTATTAAGGA AATCCCAGAG AGAGACAGCA GATACTCTCA GCCCCTGCAT GAAGAAATAG CATTGCATAA ACACCTGAAG CACAAAAATA TTGTCCAGTA TCTGGGCTCT TTCAGTGAGA ATGGTTTCAT TAAAATCTTC ATGGAGCAGG TCCCTGGAGG AAGTCTTTCT GCTCTCCTTC GTTCCAAATG GGGTCCATTA AAAGACAATG AGCAAACAAT TGGCTTTTAT ACAAAGCAAA TACTGGAAGG ATTAAAATAT CTCCATGACA ATCAGATAGT TCACCGGGAC ATAAAGGGTG ACAATGTGTT GATTAATACC TACAGTGGTG TTCTCAAGAT CTCTGACTTC GGAACATCAA AGAGGCTTGC TGGCATAAAC CCCTGTACTG AAACTTTTAC TGGTACCCTC CAGTATATGG CACCAGAAAT AATAGATAAA GGACCAAGAG GCTACGGAAA AGCAGCAGAC ATCTGGTCTC TGGGCTGTAC AATCATTGAA ATGGCCACAG GAAAACCCCC ATTTTATGAA CTGGGAGAAC CACAAGCAGC TATGTTCAAG GTGGGAATGT TTAAAGTCCA CCCTGAGATC CCAGAGTCCA TGTCTGCAGA GGCCAAGGCA TTCATACTGA AATGTTTTGA ACCAGATCCT GACAAGAGAG CCTGTGCTAA CGACTTGCTT GTTGATGAGT TTTTAAAAGT TTCAAGCAAA AAGAAAAAGA CACAACCTAA GCTTTCAGCT CTTTCAGCTG GATCAAATGA ATATCTCAGG AGTATATCCT TGCCGGTACC TGTGCTGGTG GAGGACACCA GCAGCAGCAG TGAGTACGGC TCAGTTTCAC CCGACACGGA GTTGAAAGTG GACCCCTTCT CTTTCAAAAC AAGAGCCAAG TCCTGCGGAG AAAGAGATGT CAAGGGAATT CGGACACTCT TTTTGGGCAT TCCAGATGAG AATTTTGAAG ATCACAGTGC TCCTCCTTCC CCTGAAGAAA AAGATTCTGG ATTCTTCATG CTGAGGAAGG ACAGTGAGAG GCGAGCTACC CTTCACAGGA TCCTGACGGA AGACCAAGAC AAAATTGTGA GAAACCTAAT GGAATCTTTA GCTCAGGGGG CTGAAGAACC GAAACTAAAA TGGGAACACA TCACAACCCT CATTGCAAGC CTCAGAGAAT TTGTGAGATC CACTGACCGA AAAATCATAG CCACCACACT GTCAAAGCTG AAACTGGAGC TGGACTTCGA CAGCCATGGC ATTAGCCAAG TCCAGGTGGT ACTCTTTGGT TTTCAAGATG CTGTCAATAA AGTTCTTCGG AATCATAACA TCAAGCCGCA CTGGATGTTT GCCTTAGACA GTATCATTCG GAAGGCGGTA CAGACAGCCA TTACCATCCT GGTTCCAGAA CTAAGGCCAC ATTTCAGCCT TGCATCTGAG AGTGATACTG CTGATCAAGA AGACTTGGAT GTAGAAGATG ACCATGAGGA ACAGCCTTCA AATCAAACTG TCCGAAGACC TCAGGCTGTC ATTGAAGATG CTGTGGCTAC CTCAGGCGTG AGCACGCTCA GTTCTACTGT GTCTCATGAT TCCCAGAGTG CTCACCGGTC ACTGAATGTA CAGCTTGGAA GGATGAAAAT AGAAACCAAT AGATTACTGG AAGAATTGGT TCGGAAAGAG AAAGAATTAC AAGCACTCCT TCATCGAGCT ATTGAAGAAA AAGACCAAGA AATTAAACAC CTGAAGCTTA AGTCCCAACC CATAGAAATT CCTGAATTGC CTGTATTTCA TCTAAATTCT TCTGGCACAA ATACTGAAGA TTCTGAACTT ACCGACTGGC TGAGAGTGAA TGGAGCTGAT GAAGACACTA TAAGCCGGTT TTTGGCTGAA GATTATACAC TATTGGATGT TCTCTACTAT GTTACACGTG ATGACTTAAA ATGCTTGAGA CTAAGGGGAG GGATGCTGTG CACACTGTGG AAGGCTATCA TTGACTTTCG AAACAAACAG ACTTGACTGT TGCTCAATCT AATCTTCGAT GGAAATTCTA AAAATTAATA CAGAGCTGAT CTTCTTGGGG GTGGGAAAAT CGAAGGGAGA GGAGAAAGGC GCTGCACTTT AAATCCAGTA TTTGTTTACT CATGTTAAAA AAAAAAAAAA CAGACAAAAC ACACTGAAAT TTCCTAACTA CATCTATTTC TATAATTTTT AAGGACTCTT CATAAGGACT CTTAAAATAA TCCTGAACAT TAGAACCCTA ATGTTCAGGA AGATTTTAAT CTAAGCATTT TTATGGAAAT ATTTTTAATG CAGCAGCTAT TGCACTTCAG CCAAATGTTT ATTTCACACA AAACGGATGT AACATTTCAT GTGATCGTGC ACCACTGGAA CAAAACCAAA ATGTGACCAT AACTGTTTAG GCTTCTGTGT GTTTGTAATA TGCTCTAATA ATCTGAGTAG AAATGCGTAA TTTCAATTAC TGTATAAAGT TTATGTTTTT TTAAGTGTGC AGAATCTGAG AGCAATGGTT TTTACTTCTC TGTGTTAATT GTAATATTGA CTCTATTTTG TAACTTAAGT TTCTGACCTG TCGTACATTT GTTTGAGTCG TTTATGTACT ACTGAACTGT ACCAGTTGCA CATGCTTGAA CTGTAGTAAT GTTAGCTTGT TCTAAAGCTA TCCATTGTGT CATATTTACT CTAAAAATTA AAGAGACTCT CAACAAAAAA AAAAAAAAAA AAAAA

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