RET           Alternative name(s) : RET transforming sequence ;  RET ;  hydroxyaryl protein kinase ;  c-Ret ;    Molecular Class : Receptor tyrosine kinase       Biological Process : Cell communication and signal transduction  Gene symbol :   RET   PPD ID :   HPRD_01266  Gene map locus : 10q11.2 Peptide Data MRM Exosome Data Proteinpedia Peptide sequence Investigator Sample source Short description Instrument PubMed SSTSGGGGGGGGGGGGGKSGGIVIS Dr.Timothy D. Veenstra Serum Characterization of the low molecular weight human serum proteome Microcapillary LC-MS/MS Analysis, SELDI-TOF MS 12917320 Expression Architecture Cellular Component Links OMIM 164761 Entrez Gene   5979 HGNC HGNC:9967 UniProt P07949 HPRD 01266  NetPath NetPath_M5979 PTM SNP Disease Residue Type Site Upstream enzymes Y Phosphorylation 433 RET Y Phosphorylation 775 RET Y Phosphorylation 651 RET Y Phosphorylation 842 RET Y Phosphorylation 572 RET Y Phosphorylation 808 RET Y Phosphorylation 761 RET     Protein Sequence : NP_066124.1    MAKATSGAAG LRLLLLLLLP LLGKVALGLY FSRDAYWEKL YVDQAAGTPL LYVHALRDAP EEVPSFRLGQ HLYGTYRTRL HENNWICIQE DTGLLYLNRS LDHSSWEKLS VRNRGFPLLT VYLKVFLSPT SLREGECQWP GCARVYFSFF NTSFPACSSL KPRELCFPET RPSFRIRENR PPGTFHQFRL LPVQFLCPNI SVAYRLLEGE GLPFRCAPDS LEVSTRWALD REQREKYELV AVCTVHAGAR EEVVMVPFPV TVYDEDDSAP TFPAGVDTAS AVVEFKRKED TVVATLRVFD ADVVPASGEL VRRYTSTLLP GDTWAQQTFR VEHWPNETSV QANGSFVRAT VHDYRLVLNR NLSISENRTM QLAVLVNDSD FQGPGAGVLL LHFNVSVLPV SLHLPSTYSL SVSRRARRFA QIGKVCVENC QAFSGINVQY KLHSSGANCS TLGVVTSAED TSGILFVNDT KALRRPKCAE LHYMVVATDQ QTSRQAQAQL LVTVEGSYVA EEAGCPLSCA VSKRRLECEE CGGLGSPTGR CEWRQGDGKG ITRNFSTCSP STKTCPDGHC DVVETQDINI CPQDCLRGSI VGGHEPGEPR GIKAGYGTCN CFPEEEKCFC EPEDIQDPLC DELCRTVIAA AVLFSFIVSV LLSAFCIHCY HKFAHKPPIS SAEMTFRRPA QAFPVSYSSS GARRPSLDSM ENQVSVDAFK ILEDPKWEFP RKNLVLGKTL GEGEFGKVVK ATAFHLKGRA GYTTVAVKML KENASPSELR DLLSEFNVLK QVNHPHVIKL YGACSQDGPL LLIVEYAKYG SLRGFLRESR KVGPGYLGSG GSRNSSSLDH PDERALTMGD LISFAWQISQ GMQYLAEMKL VHRDLAARNI LVAEGRKMKI SDFGLSRDVY EEDSYVKRSQ GRIPVKWMAI ESLFDHIYTT QSDVWSFGVL LWEIVTLGGN PYPGIPPERL FNLLKTGHRM ERPDNCSEEM YRLMLQCWKQ EPDKRPVFAD ISKDLEKMMV KRRDYLDLAA STPSDSLIYD DGLSEEETPL VDCNNAPLPR ALPSTWIENK LYGMSDPNWP GESPVPLTRA DGTNTGFPRY PNDSVYANWM LSPSAAKLMD TFDS Molecular weight (Da): 124318  Protein Length : 1114     Nucleotide Sequence : NM_020975.4  Open reading frame: 191 to 3535  AGTCCCGCGA CCGAAGCAGG GCGCGCAGCA GCGCTGAGTG CCCCGGAACG TGCGTCGCGC CCCCAGTGTC CGTCGCGTCC GCCGCGCCCC GGGCGGGGAT GGGGCGGCCA GACTGAGCGC CGCACCCGCC ATCCAGACCC GCCGGCCCTA GCCGCAGTCC CTCCAGCCGT GGCCCCAGCG CGCACGGGCG ATGGCGAAGG CGACGTCCGG TGCCGCGGGG CTGCGTCTGC TGTTGCTGCT GCTGCTGCCG CTGCTAGGCA AAGTGGCATT GGGCCTCTAC TTCTCGAGGG ATGCTTACTG GGAGAAGCTG TATGTGGACC AGGCGGCCGG CACGCCCTTG CTGTACGTCC ATGCCCTGCG GGACGCCCCT GAGGAGGTGC CCAGCTTCCG CCTGGGCCAG CATCTCTACG GCACGTACCG CACACGGCTG CATGAGAACA ACTGGATCTG CATCCAGGAG GACACCGGCC TCCTCTACCT TAACCGGAGC CTGGACCATA GCTCCTGGGA GAAGCTCAGT GTCCGCAACC GCGGCTTTCC CCTGCTCACC GTCTACCTCA AGGTCTTCCT GTCACCCACA TCCCTTCGTG AGGGCGAGTG CCAGTGGCCA GGCTGTGCCC GCGTATACTT CTCCTTCTTC AACACCTCCT TTCCAGCCTG CAGCTCCCTC AAGCCCCGGG AGCTCTGCTT CCCAGAGACA AGGCCCTCCT TCCGCATTCG GGAGAACCGA CCCCCAGGCA CCTTCCACCA GTTCCGCCTG CTGCCTGTGC AGTTCTTGTG CCCCAACATC AGCGTGGCCT ACAGGCTCCT GGAGGGTGAG GGTCTGCCCT TCCGCTGCGC CCCGGACAGC CTGGAGGTGA GCACGCGCTG GGCCCTGGAC CGCGAGCAGC GGGAGAAGTA CGAGCTGGTG GCCGTGTGCA CCGTGCACGC CGGCGCGCGC GAGGAGGTGG TGATGGTGCC CTTCCCGGTG ACCGTGTACG ACGAGGACGA CTCGGCGCCC ACCTTCCCCG CGGGCGTCGA CACCGCCAGC GCCGTGGTGG AGTTCAAGCG GAAGGAGGAC ACCGTGGTGG CCACGCTGCG TGTCTTCGAT GCAGACGTGG TACCTGCATC AGGGGAGCTG GTGAGGCGGT ACACAAGCAC GCTGCTCCCC GGGGACACCT GGGCCCAGCA GACCTTCCGG GTGGAACACT GGCCCAACGA GACCTCGGTC CAGGCCAACG GCAGCTTCGT GCGGGCGACC GTACATGACT ATAGGCTGGT TCTCAACCGG AACCTCTCCA TCTCGGAGAA CCGCACCATG CAGCTGGCGG TGCTGGTCAA TGACTCAGAC TTCCAGGGCC CAGGAGCGGG CGTCCTCTTG CTCCACTTCA ACGTGTCGGT GCTGCCGGTC AGCCTGCACC TGCCCAGTAC CTACTCCCTC TCCGTGAGCA GGAGGGCTCG CCGATTTGCC CAGATCGGGA AAGTCTGTGT GGAAAACTGC CAGGCATTCA GTGGCATCAA CGTCCAGTAC AAGCTGCATT CCTCTGGTGC CAACTGCAGC ACGCTAGGGG TGGTCACCTC AGCCGAGGAC ACCTCGGGGA TCCTGTTTGT GAATGACACC AAGGCCCTGC GGCGGCCCAA GTGTGCCGAA CTTCACTACA TGGTGGTGGC CACCGACCAG CAGACCTCTA GGCAGGCCCA GGCCCAGCTG CTTGTAACAG TGGAGGGGTC ATATGTGGCC GAGGAGGCGG GCTGCCCCCT GTCCTGTGCA GTCAGCAAGA GACGGCTGGA GTGTGAGGAG TGTGGCGGCC TGGGCTCCCC AACAGGCAGG TGTGAGTGGA GGCAAGGAGA TGGCAAAGGG ATCACCAGGA ACTTCTCCAC CTGCTCTCCC AGCACCAAGA CCTGCCCCGA CGGCCACTGC GATGTTGTGG AGACCCAAGA CATCAACATT TGCCCTCAGG ACTGCCTCCG GGGCAGCATT GTTGGGGGAC ACGAGCCTGG GGAGCCCCGG GGGATTAAAG CTGGCTATGG CACCTGCAAC TGCTTCCCTG AGGAGGAGAA GTGCTTCTGC GAGCCCGAAG ACATCCAGGA TCCACTGTGC GACGAGCTGT GCCGCACGGT GATCGCAGCC GCTGTCCTCT TCTCCTTCAT CGTCTCGGTG CTGCTGTCTG CCTTCTGCAT CCACTGCTAC CACAAGTTTG CCCACAAGCC ACCCATCTCC TCAGCTGAGA TGACCTTCCG GAGGCCCGCC CAGGCCTTCC CGGTCAGCTA CTCCTCTTCC GGTGCCCGCC GGCCCTCGCT GGACTCCATG GAGAACCAGG TCTCCGTGGA TGCCTTCAAG ATCCTGGAGG ATCCAAAGTG GGAATTCCCT CGGAAGAACT TGGTTCTTGG AAAAACTCTA GGAGAAGGCG AATTTGGAAA AGTGGTCAAG GCAACGGCCT TCCATCTGAA AGGCAGAGCA GGGTACACCA CGGTGGCCGT GAAGATGCTG AAAGAGAACG CCTCCCCGAG TGAGCTTCGA GACCTGCTGT CAGAGTTCAA CGTCCTGAAG CAGGTCAACC ACCCACATGT CATCAAATTG TATGGGGCCT GCAGCCAGGA TGGCCCGCTC CTCCTCATCG TGGAGTACGC CAAATACGGC TCCCTGCGGG GCTTCCTCCG CGAGAGCCGC AAAGTGGGGC CTGGCTACCT GGGCAGTGGA GGCAGCCGCA ACTCCAGCTC CCTGGACCAC CCGGATGAGC GGGCCCTCAC CATGGGCGAC CTCATCTCAT TTGCCTGGCA GATCTCACAG GGGATGCAGT ATCTGGCCGA GATGAAGCTC GTTCATCGGG ACTTGGCAGC CAGAAACATC CTGGTAGCTG AGGGGCGGAA GATGAAGATT TCGGATTTCG GCTTGTCCCG AGATGTTTAT GAAGAGGATT CCTACGTGAA GAGGAGCCAG GGTCGGATTC CAGTTAAATG GATGGCAATT GAATCCCTTT TTGATCATAT CTACACCACG CAAAGTGATG TATGGTCTTT TGGTGTCCTG CTGTGGGAGA TCGTGACCCT AGGGGGAAAC CCCTATCCTG GGATTCCTCC TGAGCGGCTC TTCAACCTTC TGAAGACCGG CCACCGGATG GAGAGGCCAG ACAACTGCAG CGAGGAGATG TACCGCCTGA TGCTGCAATG CTGGAAGCAG GAGCCGGACA AAAGGCCGGT GTTTGCGGAC ATCAGCAAAG ACCTGGAGAA GATGATGGTT AAGAGGAGAG ACTACTTGGA CCTTGCGGCG TCCACTCCAT CTGACTCCCT GATTTATGAC GACGGCCTCT CAGAGGAGGA GACACCGCTG GTGGACTGTA ATAATGCCCC CCTCCCTCGA GCCCTCCCTT CCACATGGAT TGAAAACAAA CTCTATGGCA TGTCAGACCC GAACTGGCCT GGAGAGAGTC CTGTACCACT CACGAGAGCT GATGGCACTA ACACTGGGTT TCCAAGATAT CCAAATGATA GTGTATATGC TAACTGGATG CTTTCACCCT CAGCGGCAAA ATTAATGGAC ACGTTTGATA GTTAACATTT CTTTGTGAAA GGTAATGGAC TCACAAGGGG AAGAAACATG CTGAGAATGG AAAGTCTACC GGCCCTTTCT TTGTGAACGT CACATTGGCC GAGCCGTGTT CAGTTCCCAG GTGGCAGACT CGTTTTTGGT AGTTTGTTTT AACTTCCAAG GTGGTTTTAC TTCTGATAGC CGGTGATTTT CCCTCCTAGC AGACATGCCA CACCGGGTAA GAGCTCTGAG TCTTAGTGGT TAAGCATTCC TTTCTCTTCA GTGCCCAGCA GCACCCAGTG TTGGTCTGTG TCCATCAGTG ACCACCAACA TTCTGTGTTC ACATGTGTGG GTCCAACACT TACTACCTGG TGTATGAAAT TGGACCTGAA CTGTTGGATT TTTCTAGTTG CCGCCAAACA AGGCAAAAAA ATTTAAACAT GAAGCACACA CACAAAAAAG GCAGTAGGAA AAATGCTGGC CCTGATGACC TGTCCTTATT CAGAATGAGA GACTGCGGGG GGGGCCTGGG GGTAGTGTCA ATGCCCCTCC AGGGCTGGAG GGGAAGAGGG GCCCCGAGGA TGGGCCTGGG CTCAGCATTC GAGATCTTGA GAATGATTTT TTTTTAATCA TGCAACCTTT CCTTAGGAAG ACATTTGGTT TTCATCATGA TTAAGATGAT TCCTAGATTT AGCACAATGG AGAGATTCCA TGCCATCTTT ACTATGTGGA TGGTGGTATC AGGGAAGAGG GCTCACAAGA CACATTTGTC CCCCGGGCCC ACCACATCAT CCTCACGTGT TCGGTACTGA GCAGCCACTA CCCCTGATGA GAACAGTATG AAGAAAGGGG GCTGTTGGAG TCCCAGAATT GCTGACAGCA GAGGCTTTGC TGCTGTGAAT CCCACCTGCC ACCAGCCTGC AGCACACCCC ACAGCCAAGT AGAGGCGAAA GCAGTGGCTC ATCCTACCTG TTAGGAGCAG GTAGGGCTTG TACTCACTTT AATTTGAATC TTATCAACTT ACTCATAAAG GGACAGGCTA GCTAGCTGTG TTAGAAGTAG CAATGACAAT GACCAAGGAC TGCTACACCT CTGATTACAA TTCTGATGTG AAAAAGATGG TGTTTGGCTC TTATAGAGCC TGTGTGAAAG GCCCATGGAT CAGCTCTTCC TGTGTTTGTA ATTTAATGCT GCTACAAGAT GTTTCTGTTT CTTAGATTCT GACCATGACT CATAAGCTTC TTGTCATTCT TCATTGCTTG TTTGTGGTCA CAGATGCACA ACACTCCTCC AGTCTTGTGG GGGCAGCTTT TGGGAAGTCT CAGCAGCTCT TCTGGCTGTG TTGTCAGCAC TGTAACTTCG CAGAAAAGAG TCGGATTACC AAAACACTGC CTGCTCTTCA GACTTAAAGC ACTGATAGGA CTTAAAATAG TCTCATTCAA ATACTGTATT TTATATAGGC ATTTCACAAA AACAGCAAAA TTGTGGCATT TTGTGAGGCC AAGGCTTGGA TGCGTGTGTA ATAGAGCCTT GTGGTGTGTG CGCACACACC CAGAGGGAGA GTTTGAAAAA TGCTTATTGG ACACGTAACC TGGCTCTAAT TTGGGCTGTT TTTCAGATAC ACTGTGATAA GTTCTTTTAC AAATATCTAT AGACATGGTA AACTTTTGGT TTTCAGATAT GCTTAATGAT AGTCTTACTA AATGCAGAAA TAAGAATAAA CTTTCTCAAA TTATTAAAAA TGCCTACACA GTAAGTGTGA ATTGCTGCAA CAGGTTTGTT CTCAGGAGGG TAAGAACTCC AGGTCTAAAC AGCTGACCCA GTGATGGGGA ATTTATCCTT GACCAATTTA TCCTTGACCA ATAACCTAAT TGTCTATTCC TGAGTTATAA AAGTCCCCAT CCTTATTAGC TCTACTGGAA TTTTCATACA CGTAAATGCA GAAGTTACTA AGTATTAAGT ATTACTGAGT ATTAAGTAGT AATCTGTCAG TTATTAAAAT TTGTAAAATC TATTTATGAA AGGTCATTAA ACCAGATCAT GTTCCTTTTT TTGTAATCAA GGTGACTAAG AAAATCAGTT GTGTAAATAA AATCATGTAT CATAAAAAAA AAAAAAAAA

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